SidaGhanaV1, Main, Exploration, bibRecord, 000628

Anaemia and zidovudine-containing antiretroviral therapy in paediatric antiretroviral programmes in the IeDEA Paediatric West African Database to evaluate AIDS

Identifieur interne : 000628 ( Main/Exploration ); précédent : 000627; suivant : 000629

Anaemia and zidovudine-containing antiretroviral therapy in paediatric antiretroviral programmes in the IeDEA Paediatric West African Database to evaluate AIDS

Auteurs : Lorna A. Renner [Ghana] ; Fatoumata Dicko [Mali] ; Fla Kouéta [Burkina Faso] ; Karen Malateste [France] ; Ramatoulaye D. Gueye [Sénégal] ; Edmond Aka [Côte d'Ivoire] ; Tanoh K. Eboua [Côte d'Ivoire] ; Alain Azondékon [Bénin] ; Uduok Okomo [Gambie] ; Pety Touré ; Didier Ekouévi [Côte d'Ivoire] ; Valeriane Leroy [France]

Source :

Journal of the International AIDS Society [ 1758-2652 ] ; 2013.

RBID : PMC:3776924

Descripteurs français

KwdFr :
- Afrique de l'Ouest (épidémiologie), Agents antiVIH (effets indésirables), Agents antiVIH (usage thérapeutique), Animaux, Anémie (), Anémie (épidémiologie), Enfant, Enfant d'âge préscolaire, Femelle, Humains, Infections à VIH (), Infections à VIH (traitement médicamenteux), Mâle, Thérapie antirétrovirale hautement active (), Thérapie antirétrovirale hautement active (effets indésirables), Zidovudine (effets indésirables), Zidovudine (usage thérapeutique), Études rétrospectives.
MESH :
- effets indésirables : Agents antiVIH, Thérapie antirétrovirale hautement active, Zidovudine.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH, Zidovudine.
- épidémiologie : Afrique de l'Ouest, Anémie.
- Animaux, Anémie, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Infections à VIH, Mâle, Thérapie antirétrovirale hautement active, Études rétrospectives.

English descriptors

KwdEn :
- Africa, Western (epidemiology), Anemia (chemically induced), Anemia (epidemiology), Animals, Anti-HIV Agents (adverse effects), Anti-HIV Agents (therapeutic use), Antiretroviral Therapy, Highly Active (adverse effects), Antiretroviral Therapy, Highly Active (methods), Child, Child, Preschool, Female, HIV Infections (complications), HIV Infections (drug therapy), Humans, Male, Retrospective Studies, Zidovudine (adverse effects), Zidovudine (therapeutic use).
MESH :
- chemical , adverse effects : Anti-HIV Agents, Zidovudine.
- geographic , epidemiology : Africa, Western.
- adverse effects : Antiretroviral Therapy, Highly Active.
- chemically induced : Anemia.
- complications : HIV Infections.
- drug therapy : HIV Infections.
- epidemiology : Anemia.
- methods : Antiretroviral Therapy, Highly Active.
- chemical , therapeutic use : Anti-HIV Agents, Zidovudine.
- Animals, Child, Child, Preschool, Female, Humans, Male, Retrospective Studies.

Abstract

Introduction

There is a risk of anaemia among HIV-infected children on antiretroviral therapy (ART) containing zidovudine (ZDV) recommended in first-line regimens in the WHO guidelines. We estimated the risk of severe anaemia after initiation of a ZDV-containing regimen in HIV-infected children included in the IeDEA West African database.

Methods

Standardized collection of data from HIV-infected children (positive PCR<18 months or positive serology ≥18 months) followed up in HIV programmes was included in the regional IeDEA West Africa collaboration. Ten clinical centres from seven countries contributed (Benin, Burkina Faso, Côte d'Ivoire, Gambia, Ghana, Mali and Senegal) to this collection. Inclusion criteria were age <16 years and starting ART. We explored the data quality of haemoglobin documentation over time and the incidence and predictors of severe anaemia (Hb<7g/dL) per 100 child-years of follow-up over the duration of first-line antiretroviral therapy.

Results

As of December 2009, among the 2933 children included in the collaboration, 45% were girls, median age was five years; median CD4 cell percentage was 13%; median weight-for-age z-score was −2.7; and 1772 (60.4%) had a first-line ZDV-containing regimen. At baseline, 70% of the children with a first-line ZDV-containing regimen had a haemoglobin measure available versus 76% in those not on ZDV (p≤0.01): the prevalence of severe anaemia was 3.0% (n=38) in the ZDV group versus 10.2% (n=89) in those without (p<0. 01). Over the first-line follow-up, 58.9% of the children had ≥1 measure of haemoglobin available in those exposed to ZDV versus 60.4% of those not (p=0.45). Severe anaemia occurred in 92 children with an incidence of 2.47 per 100 child-years of follow-up in those on a ZDV-containing regimen versus 4.25 in those not (p≤0.01). Adjusted for age at ART initiation and first-line regimen, a weight-for-age z-score ≤−3 was a strong predictor associated with a 5.59 times risk of severe anaemia (p<0.01).

Conclusions

Severe anaemia is frequent at baseline and guides the first-line ART prescription, but its incidence seems rare among children on ART. Severe malnutrition at baseline is a strong predictor for development of severe anaemia, and interventions to address this should form an integral component of clinical care.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776924

DOI: 10.7448/IAS.16.1.18024
PubMed: 24047928
PubMed Central: 3776924

Affiliations:

Burkina Faso, Bénin, Côte d'Ivoire, France, Gambie, Ghana, Mali, Sénégal
Aquitaine, Nouvelle-Aquitaine, Région du Grand Accra
Accra, Bordeaux
Université Bordeaux II

Le document en format XML

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<term>Animals</term>
<term>Anti-HIV Agents (adverse effects)</term>
<term>Anti-HIV Agents (therapeutic use)</term>
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<term>Anémie ()</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Antiretroviral Therapy, Highly Active</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term>
<term>Zidovudine</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term>
<term>Zidovudine</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Afrique de l'Ouest</term>
<term>Anémie</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Retrospective Studies</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Anémie</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à VIH</term>
<term>Mâle</term>
<term>Thérapie antirétrovirale hautement active</term>
<term>Études rétrospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="st1"><title>Introduction</title>
<p>There is a risk of anaemia among HIV-infected children on antiretroviral therapy (ART) containing zidovudine (ZDV) recommended in first-line regimens in the WHO guidelines. We estimated the risk of severe anaemia after initiation of a ZDV-containing regimen in HIV-infected children included in the IeDEA West African database.</p>
</sec>
<sec id="st2"><title>Methods</title>
<p>Standardized collection of data from HIV-infected children (positive PCR<18 months or positive serology ≥18 months) followed up in HIV programmes was included in the regional IeDEA West Africa collaboration. Ten clinical centres from seven countries contributed (Benin, Burkina Faso, Côte d'Ivoire, Gambia, Ghana, Mali and Senegal) to this collection. Inclusion criteria were age <16 years and starting ART. We explored the data quality of haemoglobin documentation over time and the incidence and predictors of severe anaemia (Hb<7g/dL) per 100 child-years of follow-up over the duration of first-line antiretroviral therapy.</p>
</sec>
<sec id="st3"><title>Results</title>
<p>As of December 2009, among the 2933 children included in the collaboration, 45% were girls, median age was five years; median CD4 cell percentage was 13%; median weight-for-age <italic>z</italic>
-score was −2.7; and 1772 (60.4%) had a first-line ZDV-containing regimen. At baseline, 70% of the children with a first-line ZDV-containing regimen had a haemoglobin measure available versus 76% in those not on ZDV (<italic>p</italic>
≤0.01): the prevalence of severe anaemia was 3.0% (<italic>n</italic>
=38) in the ZDV group versus 10.2% (<italic>n</italic>
=89) in those without (<italic>p</italic>
<0. 01). Over the first-line follow-up, 58.9% of the children had ≥1 measure of haemoglobin available in those exposed to ZDV versus 60.4% of those not (<italic>p</italic>
=0.45). Severe anaemia occurred in 92 children with an incidence of 2.47 per 100 child-years of follow-up in those on a ZDV-containing regimen versus 4.25 in those not (<italic>p≤</italic>
0.01). Adjusted for age at ART initiation and first-line regimen, a weight-for-age <italic>z</italic>
-score ≤−3 was a strong predictor associated with a 5.59 times risk of severe anaemia (<italic>p</italic>
<0.01).</p>
</sec>
<sec id="st4"><title>Conclusions</title>
<p>Severe anaemia is frequent at baseline and guides the first-line ART prescription, but its incidence seems rare among children on ART. Severe malnutrition at baseline is a strong predictor for development of severe anaemia, and interventions to address this should form an integral component of clinical care.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Laufer, Mk" uniqKey="Laufer M">MK Laufer</name>
</author>
<author><name sortKey="Van Oosterhout, Jj" uniqKey="Van Oosterhout J">JJ van Oosterhout</name>
</author>
<author><name sortKey="Perez, Ma" uniqKey="Perez M">MA Perez</name>
</author>
<author><name sortKey="Kanyanganlika, J" uniqKey="Kanyanganlika J">J Kanyanganlika</name>
</author>
<author><name sortKey="Taylor, Te" uniqKey="Taylor T">TE Taylor</name>
</author>
<author><name sortKey="Plowe, Cv" uniqKey="Plowe C">CV Plowe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Calis, Jc" uniqKey="Calis J">JC Calis</name>
</author>
<author><name sortKey="Van Hensbroek, Mb" uniqKey="Van Hensbroek M">MB van Hensbroek</name>
</author>
<author><name sortKey="De Haan, Rj" uniqKey="De Haan R">RJ de Haan</name>
</author>
<author><name sortKey="Moons, P" uniqKey="Moons P">P Moons</name>
</author>
<author><name sortKey="Brabin, Bj" uniqKey="Brabin B">BJ Brabin</name>
</author>
<author><name sortKey="Bates, I" uniqKey="Bates I">I Bates</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clark, Td" uniqKey="Clark T">TD Clark</name>
</author>
<author><name sortKey="Mmiro, F" uniqKey="Mmiro F">F Mmiro</name>
</author>
<author><name sortKey="Ndugwa, C" uniqKey="Ndugwa C">C Ndugwa</name>
</author>
<author><name sortKey="Perry, Rt" uniqKey="Perry R">RT Perry</name>
</author>
<author><name sortKey="Jackson, Jb" uniqKey="Jackson J">JB Jackson</name>
</author>
<author><name sortKey="Melikian, G" uniqKey="Melikian G">G Melikian</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Okechukwu, Aa" uniqKey="Okechukwu A">AA Okechukwu</name>
</author>
<author><name sortKey="Gambo, D" uniqKey="Gambo D">D Gambo</name>
</author>
<author><name sortKey="Okechukwu, Io" uniqKey="Okechukwu I">IO Okechukwu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fassinou, P" uniqKey="Fassinou P">P Fassinou</name>
</author>
<author><name sortKey="Elenga, N" uniqKey="Elenga N">N Elenga</name>
</author>
<author><name sortKey="Rouet, F" uniqKey="Rouet F">F Rouet</name>
</author>
<author><name sortKey="Laguide, R" uniqKey="Laguide R">R Laguide</name>
</author>
<author><name sortKey="Kouakoussui, Ka" uniqKey="Kouakoussui K">KA Kouakoussui</name>
</author>
<author><name sortKey="Timite, M" uniqKey="Timite M">M Timite</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Cornet, M" uniqKey="Cornet M">M Cornet</name>
</author>
<author><name sortKey="Le Hesran, Jy" uniqKey="Le Hesran J">JY Le Hesran</name>
</author>
<author><name sortKey="Fievet, N" uniqKey="Fievet N">N Fievet</name>
</author>
<author><name sortKey="Cot, M" uniqKey="Cot M">M Cot</name>
</author>
<author><name sortKey="Personne, P" uniqKey="Personne P">P Personne</name>
</author>
<author><name sortKey="Gounoue, R" uniqKey="Gounoue R">R Gounoue</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heckman, J" uniqKey="Heckman J">J Heckman</name>
</author>
<author><name sortKey="Samie, A" uniqKey="Samie A">A Samie</name>
</author>
<author><name sortKey="Bessong, P" uniqKey="Bessong P">P Bessong</name>
</author>
<author><name sortKey="Ntsieni, M" uniqKey="Ntsieni M">M Ntsieni</name>
</author>
<author><name sortKey="Hamandi, H" uniqKey="Hamandi H">H Hamandi</name>
</author>
<author><name sortKey="Kohler, M" uniqKey="Kohler M">M Kohler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Greenwell, F" uniqKey="Greenwell F">F Greenwell</name>
</author>
<author><name sortKey="Neumann, M" uniqKey="Neumann M">M Neumann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eley, Bs" uniqKey="Eley B">BS Eley</name>
</author>
<author><name sortKey="Sive, Aa" uniqKey="Sive A">AA Sive</name>
</author>
<author><name sortKey="Shuttleworth, M" uniqKey="Shuttleworth M">M Shuttleworth</name>
</author>
<author><name sortKey="Hussy, Gd" uniqKey="Hussy G">GD Hussy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shet, A" uniqKey="Shet A">A Shet</name>
</author>
<author><name sortKey="Mehta, S" uniqKey="Mehta S">S Mehta</name>
</author>
<author><name sortKey="Rajagopalan, N" uniqKey="Rajagopalan N">N Rajagopalan</name>
</author>
<author><name sortKey="Dinakar, C" uniqKey="Dinakar C">C Dinakar</name>
</author>
<author><name sortKey="Ramesh, E" uniqKey="Ramesh E">E Ramesh</name>
</author>
<author><name sortKey="Samuel, Nm" uniqKey="Samuel N">NM Samuel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Owiredu, Wkba" uniqKey="Owiredu W">WKBA Owiredu</name>
</author>
<author><name sortKey="Quaye, L" uniqKey="Quaye L">L Quaye</name>
</author>
<author><name sortKey="Amidu, N" uniqKey="Amidu N">N Amidu</name>
</author>
<author><name sortKey="Addai Mensah, O" uniqKey="Addai Mensah O">O Addai-Mensah</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Kiragga, A" uniqKey="Kiragga A">A Kiragga</name>
</author>
<author><name sortKey="Castelnuovo, B" uniqKey="Castelnuovo B">B Castelnuovo</name>
</author>
<author><name sortKey="Nakanjako, D" uniqKey="Nakanjako D">D Nakanjako</name>
</author>
<author><name sortKey="Manabe, Yc" uniqKey="Manabe Y">YC Manabe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weigel, R" uniqKey="Weigel R">R Weigel</name>
</author>
<author><name sortKey="Hochgesang, M" uniqKey="Hochgesang M">M Hochgesang</name>
</author>
<author><name sortKey="Brinkhof, Mw" uniqKey="Brinkhof M">MW Brinkhof</name>
</author>
<author><name sortKey="Hosseinipour, Mc" uniqKey="Hosseinipour M">MC Hosseinipour</name>
</author>
<author><name sortKey="Boxshall, M" uniqKey="Boxshall M">M Boxshall</name>
</author>
<author><name sortKey="Mhango, E" uniqKey="Mhango E">E Mhango</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vreeman, Rc" uniqKey="Vreeman R">RC Vreeman</name>
</author>
<author><name sortKey="Wiehe, Se" uniqKey="Wiehe S">SE Wiehe</name>
</author>
<author><name sortKey="Ayaya, So" uniqKey="Ayaya S">SO Ayaya</name>
</author>
<author><name sortKey="Musick, Bs" uniqKey="Musick B">BS Musick</name>
</author>
<author><name sortKey="Nyandiko, Wm" uniqKey="Nyandiko W">WM Nyandiko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meyers, T" uniqKey="Meyers T">T Meyers</name>
</author>
<author><name sortKey="Moultrie, H" uniqKey="Moultrie H">H Moultrie</name>
</author>
<author><name sortKey="Naidoo, K" uniqKey="Naidoo K">K Naidoo</name>
</author>
<author><name sortKey="Cotton, M" uniqKey="Cotton M">M Cotton</name>
</author>
<author><name sortKey="Eley, B" uniqKey="Eley B">B Eley</name>
</author>
<author><name sortKey="Sherman, G" uniqKey="Sherman G">G Sherman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fenner, L" uniqKey="Fenner L">L Fenner</name>
</author>
<author><name sortKey="Brinkhof, Mwg" uniqKey="Brinkhof M">MWG Brinkhof</name>
</author>
<author><name sortKey="Keiser, O" uniqKey="Keiser O">O Keiser</name>
</author>
<author><name sortKey="Weigel, R" uniqKey="Weigel R">R Weigel</name>
</author>
<author><name sortKey="Cornell, M" uniqKey="Cornell M">M Cornell</name>
</author>
<author><name sortKey="Moultrie, H" uniqKey="Moultrie H">H Moultrie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Davies, Ma" uniqKey="Davies M">MA Davies</name>
</author>
<author><name sortKey="Keiser, O" uniqKey="Keiser O">O Keiser</name>
</author>
<author><name sortKey="Technau, K" uniqKey="Technau K">K Technau</name>
</author>
<author><name sortKey="Eley, B" uniqKey="Eley B">B Eley</name>
</author>
<author><name sortKey="Rabie, H" uniqKey="Rabie H">H Rabie</name>
</author>
<author><name sortKey="Van Cutsem, G" uniqKey="Van Cutsem G">G van Cutsem</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Whitescarter, J" uniqKey="Whitescarter J">J Whitescarter</name>
</author>
<author><name sortKey="Miotti, P" uniqKey="Miotti P">P Miotti</name>
</author>
<author><name sortKey="Bazin, B" uniqKey="Bazin B">B Bazin</name>
</author>
<author><name sortKey="Blesson, S" uniqKey="Blesson S">S Blesson</name>
</author>
<author><name sortKey="Arrive, E" uniqKey="Arrive E">E Arrive</name>
</author>
<author><name sortKey="Marquis, B" uniqKey="Marquis B">B Marquis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bolton Moore, C" uniqKey="Bolton Moore C">C Bolton-Moore</name>
</author>
<author><name sortKey="Mubiana Mbewe, M" uniqKey="Mubiana Mbewe M">M Mubiana-Mbewe</name>
</author>
<author><name sortKey="Cantrell, R" uniqKey="Cantrell R">R Cantrell</name>
</author>
<author><name sortKey="Chintu, N" uniqKey="Chintu N">N Chintu</name>
</author>
<author><name sortKey="Stringer, Em" uniqKey="Stringer E">EM Stringer</name>
</author>
<author><name sortKey="Chi, Bh" uniqKey="Chi B">BH Chi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wamalwa, Dc" uniqKey="Wamalwa D">DC Wamalwa</name>
</author>
<author><name sortKey="Obimbo, E" uniqKey="Obimbo E">E Obimbo</name>
</author>
<author><name sortKey="Farquhar, C" uniqKey="Farquhar C">C Farquhar</name>
</author>
<author><name sortKey="Richardson, Ba" uniqKey="Richardson B">BA Richardson</name>
</author>
<author><name sortKey="Mbori Ngacha, Da" uniqKey="Mbori Ngacha D">DA Mbori-Ngacha</name>
</author>
<author><name sortKey="Inwani, I" uniqKey="Inwani I">I Inwani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Volberding, Pa" uniqKey="Volberding P">PA Volberding</name>
</author>
<author><name sortKey="Levine, Am" uniqKey="Levine A">AM Levine</name>
</author>
<author><name sortKey="Dietrich, D" uniqKey="Dietrich D">D Dietrich</name>
</author>
<author><name sortKey="Mildvan, D" uniqKey="Mildvan D">D Mildvan</name>
</author>
<author><name sortKey="Mitsuvasu, R" uniqKey="Mitsuvasu R">R Mitsuvasu</name>
</author>
<author><name sortKey="Saaq, M" uniqKey="Saaq M">M Saaq</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Aurpibul, L" uniqKey="Aurpibul L">L Aurpibul</name>
</author>
<author><name sortKey="Puthanakit, T" uniqKey="Puthanakit T">T Puthanakit</name>
</author>
<author><name sortKey="Sirisanthana, T" uniqKey="Sirisanthana T">T Sirisanthana</name>
</author>
<author><name sortKey="Sirisanthana, V" uniqKey="Sirisanthana V">V Sirisanthana</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Midvan, D" uniqKey="Midvan D">D Midvan</name>
</author>
<author><name sortKey="Creagh, T" uniqKey="Creagh T">T Creagh</name>
</author>
<author><name sortKey="Leitz, G" uniqKey="Leitz G">G Leitz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Forna, F" uniqKey="Forna F">F Forna</name>
</author>
<author><name sortKey="Moore, D" uniqKey="Moore D">D Moore</name>
</author>
<author><name sortKey="Mermin, J" uniqKey="Mermin J">J Mermin</name>
</author>
<author><name sortKey="Brooks, Jt" uniqKey="Brooks J">JT Brooks</name>
</author>
<author><name sortKey="Were, W" uniqKey="Were W">W Were</name>
</author>
<author><name sortKey="Buchacz, K" uniqKey="Buchacz K">K Buchacz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huffam, Se" uniqKey="Huffam S">SE Huffam</name>
</author>
<author><name sortKey="Srasuebkul, P" uniqKey="Srasuebkul P">P Srasuebkul</name>
</author>
<author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name>
</author>
<author><name sortKey="Calmy, A" uniqKey="Calmy A">A Calmy</name>
</author>
<author><name sortKey="Saphonn, V" uniqKey="Saphonn V">V Saphonn</name>
</author>
<author><name sortKey="Kaldor, Jm" uniqKey="Kaldor J">JM Kaldor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rajesh, R" uniqKey="Rajesh R">R Rajesh</name>
</author>
<author><name sortKey="Vidyasagar, S" uniqKey="Vidyasagar S">S Vidyasagar</name>
</author>
<author><name sortKey="Varma, Dm" uniqKey="Varma D">DM Varma</name>
</author>
<author><name sortKey="Mohiuddin, S" uniqKey="Mohiuddin S">S Mohiuddin</name>
</author>
<author><name sortKey="Noorunnisa" uniqKey="Noorunnisa">Noorunnisa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Agarwal, D" uniqKey="Agarwal D">D Agarwal</name>
</author>
<author><name sortKey="Chakravarty, J" uniqKey="Chakravarty J">J Chakravarty</name>
</author>
<author><name sortKey="Chaube, L" uniqKey="Chaube L">L Chaube</name>
</author>
<author><name sortKey="Rai, M" uniqKey="Rai M">M Rai</name>
</author>
<author><name sortKey="Agrawal, Nr" uniqKey="Agrawal N">NR Agrawal</name>
</author>
<author><name sortKey="Sundar, S" uniqKey="Sundar S">S Sundar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anwikar, Sr" uniqKey="Anwikar S">SR Anwikar</name>
</author>
<author><name sortKey="Bandekar, Ms" uniqKey="Bandekar M">MS Bandekar</name>
</author>
<author><name sortKey="Smrati, B" uniqKey="Smrati B">B Smrati</name>
</author>
<author><name sortKey="Pazare, Ap" uniqKey="Pazare A">AP Pazare</name>
</author>
<author><name sortKey="Tatke, Pa" uniqKey="Tatke P">PA Tatke</name>
</author>
<author><name sortKey="Kshirsagar, Na" uniqKey="Kshirsagar N">NA Kshirsagar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sullivan, Ps" uniqKey="Sullivan P">PS Sullivan</name>
</author>
<author><name sortKey="Hanson, Dl" uniqKey="Hanson D">DL Hanson</name>
</author>
<author><name sortKey="Brooks, Jt" uniqKey="Brooks J">JT Brooks</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brabin, Bj" uniqKey="Brabin B">BJ Brabin</name>
</author>
<author><name sortKey="Premji, Z" uniqKey="Premji Z">Z Premji</name>
</author>
<author><name sortKey="Verheff, F" uniqKey="Verheff F">F Verheff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ssali, F" uniqKey="Ssali F">F SSali</name>
</author>
<author><name sortKey="Stohr, W" uniqKey="Stohr W">W Stohr</name>
</author>
<author><name sortKey="Munderi, P" uniqKey="Munderi P">P Munderi</name>
</author>
<author><name sortKey="Reid, A" uniqKey="Reid A">A Reid</name>
</author>
<author><name sortKey="Walker, As" uniqKey="Walker A">AS Walker</name>
</author>
<author><name sortKey="Gibb, Dm" uniqKey="Gibb D">DM Gibb</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Burkina Faso</li>
<li>Bénin</li>
<li>Côte d'Ivoire</li>
<li>France</li>
<li>Gambie</li>
<li>Ghana</li>
<li>Mali</li>
<li>Sénégal</li>
</country>
<region><li>Aquitaine</li>
<li>Nouvelle-Aquitaine</li>
<li>Région du Grand Accra</li>
</region>
<settlement><li>Accra</li>
<li>Bordeaux</li>
</settlement>
<orgName><li>Université Bordeaux II</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Toure, Pety" sort="Toure, Pety" uniqKey="Toure P" first="Pety" last="Touré">Pety Touré</name>
</noCountry>
<country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Renner, Lorna A" sort="Renner, Lorna A" uniqKey="Renner L" first="Lorna A" last="Renner">Lorna A. Renner</name>
</region>
</country>
<country name="Mali"><noRegion><name sortKey="Dicko, Fatoumata" sort="Dicko, Fatoumata" uniqKey="Dicko F" first="Fatoumata" last="Dicko">Fatoumata Dicko</name>
</noRegion>
</country>
<country name="Burkina Faso"><noRegion><name sortKey="Koueta, Fla" sort="Koueta, Fla" uniqKey="Koueta F" first="Fla" last="Kouéta">Fla Kouéta</name>
</noRegion>
</country>
<country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Malateste, Karen" sort="Malateste, Karen" uniqKey="Malateste K" first="Karen" last="Malateste">Karen Malateste</name>
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<name sortKey="Leroy, Valeriane" sort="Leroy, Valeriane" uniqKey="Leroy V" first="Valeriane" last="Leroy">Valeriane Leroy</name>
</country>
<country name="Sénégal"><noRegion><name sortKey="Gueye, Ramatoulaye D" sort="Gueye, Ramatoulaye D" uniqKey="Gueye R" first="Ramatoulaye D" last="Gueye">Ramatoulaye D. Gueye</name>
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</country>
<country name="Côte d'Ivoire"><noRegion><name sortKey="Aka, Edmond" sort="Aka, Edmond" uniqKey="Aka E" first="Edmond" last="Aka">Edmond Aka</name>
</noRegion>
<name sortKey="Eboua, Tanoh K" sort="Eboua, Tanoh K" uniqKey="Eboua T" first="Tanoh K" last="Eboua">Tanoh K. Eboua</name>
<name sortKey="Ekouevi, Didier" sort="Ekouevi, Didier" uniqKey="Ekouevi D" first="Didier" last="Ekouévi">Didier Ekouévi</name>
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<country name="Bénin"><noRegion><name sortKey="Azondekon, Alain" sort="Azondekon, Alain" uniqKey="Azondekon A" first="Alain" last="Azondékon">Alain Azondékon</name>
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</country>
<country name="Gambie"><noRegion><name sortKey="Okomo, Uduok" sort="Okomo, Uduok" uniqKey="Okomo U" first="Uduok" last="Okomo">Uduok Okomo</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaGhanaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000628 | SxmlIndent | more

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{{Explor lien
   |wiki=    Wicri/Sante
   |area=    SidaGhanaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3776924
   |texte=   Anaemia and zidovudine-containing antiretroviral therapy in paediatric antiretroviral programmes in the IeDEA Paediatric West African Database to evaluate AIDS
}}

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       | NlmPubMed2Wicri -a SidaGhanaV1

This area was generated with Dilib version V0.6.31.
Data generation: Tue Nov 7 18:07:38 2017. Site generation: Tue Mar 5 15:01:57 2024

Le SIDA au Ghana (serveur d'exploration)

Anaemia and zidovudine-containing antiretroviral therapy in paediatric antiretroviral programmes in the IeDEA Paediatric West African Database to evaluate AIDS

Anaemia and zidovudine-containing antiretroviral therapy in paediatric antiretroviral programmes in the IeDEA Paediatric West African Database to evaluate AIDS

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Abstract

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Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Le SIDA au Ghana (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.